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Yongzheng Chen Selected Research

Podophyllotoxin (Condylox)

1/2019Novel hybrids of podophyllotoxin and formononetin inhibit the growth, migration and invasion of lung cancer cells.
10/2018Design, synthesis and biological evaluation of novel nitric oxide-donating podophyllotoxin derivatives as potential antiproliferative agents against multi-drug resistant leukemia cells.
1/2018Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents.
5/2017Synthesis and biological evaluation of novel podophyllotoxin-NSAIDs conjugates as multifunctional anti-MDR agents against resistant human hepatocellular carcinoma Bel-7402/5-FU cells.
11/2016Aromatic heterocyclic esters of podophyllotoxin exert anti-MDR activity in human leukemia K562/ADR cells via ROS/MAPK signaling pathways.
1/2016Synthesis and biological evaluation of a novel artesunate-podophyllotoxin conjugate as anticancer agent.
1/2016Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells.

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Yongzheng Chen Research Topics

Disease

5Leukemia
12/2019 - 01/2016
4BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
11/2021 - 01/2016
3Neoplasms (Cancer)
01/2018 - 01/2016
1Thyroid Neoplasms (Thyroid Cancer)
01/2022
1Lung Diseases (Lung Disease)
01/2021
1Cardiovascular Diseases (Cardiovascular Disease)
01/2021
1Lung Neoplasms (Lung Cancer)
01/2019
1Dehydration (Water Stress)
10/2017
1Hepatocellular Carcinoma (Hepatoma)
05/2017
1Carcinoma (Carcinomatosis)
11/2016

Drug/Important Bio-Agent (IBA)

7Podophyllotoxin (Condylox)FDA LinkGeneric
01/2019 - 01/2016
4Pharmaceutical PreparationsIBA
12/2019 - 01/2016
3Biological ProductsIBA
12/2019 - 05/2017
3Antineoplastic Agents (Antineoplastics)IBA
01/2018 - 11/2016
2indirubinIBA
11/2021 - 01/2018
2EstersIBA
11/2016 - 01/2016
1Long Noncoding RNAIBA
01/2022
1Biomarkers (Surrogate Marker)IBA
01/2022
1Indicators and Reagents (Reagents)IBA
01/2022
1Qingdai compoundIBA
11/2021
1ImipenemFDA Link
01/2021
1VancomycinFDA LinkGeneric
01/2021
1Beclin-1IBA
12/2019
1HomoharringtonineIBA
12/2019
1formononetinIBA
01/2019
1Nitric Oxide (Nitrogen Monoxide)FDA Link
10/2018
1Hydrochloric Acid (Hydrogen Chloride)FDA Link
10/2017
1ThioureaIBA
10/2017
1indolineIBA
10/2017
1cinchonidineIBA
10/2017
1Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
05/2017
1AcidsIBA
01/2016
1pyridineIBA
01/2016
1ArtesunateIBA
01/2016
1SincalideFDA Link
01/2016

Therapy/Procedure

2Drug Therapy (Chemotherapy)
10/2018 - 05/2017
1Chinese Traditional Medicine (Traditional Chinese Medicine)
11/2021
1Therapeutics
11/2021
1Artificial Respiration (Mechanical Ventilation)
01/2021